Our research is at the interface of analytical chemistry, chemical biology, and material science, and aims to address outstanding challenges in the biomedical sciences. Initial directions will focus on the synthesis of sophisticated DNA and protein-based materials as chemical tools for the quantitative analysis and manipulation of live-cell analytes with single-cell resolution, ultimately leading to the development of improved diagnostic and therapeutic systems.

DNA-Programmable Enzymes

Our goal is to develop a new class of live-cell probes and prodrugs based on enzyme-oligonucleotide conjugates.

Profiling Single-Cell Protease Activity

Protease activity is highly dysregulated in diseases such as cancer. We aim to develop the first scalable approach that allows high-throughput, multiplexed measurement of protease activity in single cells.

Structurally Precise Enzyme Assemblies

We seek to employ DNA-mediated assembly to synthesize supramolecular structures in which a discrete number of proteins can be arranged precisely in three dimensions with control over composition, stoichiometry, and position.